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BPC-157

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Research brief

BPC-157 — Canada Research Brief

Last updated April 11, 2026

BPC-157 is a 15-amino-acid synthetic peptide derived from a protein in human gastric juice, studied in preclinical research for tissue repair via the VEGFR2 / angiogenesis pathway.

Key facts

Canonical nameBPC-157
Alternate namesBody Protection Compound 157, PL 14736, Bepecin, Pentadecapeptide BPC 157
Drug classSynthetic gastric pentadecapeptide (healing / cytoprotective)
CAS number137525-51-0
Molecular formulaC62H98N16O22
Molecular weight1419.56 g/mol
SequenceGly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
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Reconstitution Guide

Add bacteriostatic water to achieve your desired concentration:

1ml BAC water5.0mg/ml
2ml BAC water2.5mg/ml
2.5ml BAC water2.0mg/ml

Inject water slowly against vial wall. Swirl gently, do not shake.

About This Product

BPC-157 Canada - Body Protection Compound for Tissue Research BPC-157, a 15-amino acid sequence derived from human gastric juice, has captured significant attention in regenerative research circles. This pentadecapeptide demonstrates remarkable stability and activity in both in-vitro and animal studies, making it a valuable tool for tissue repair investigation. MOLECULAR CHARACTERISTICS BPC-157's unique sequence (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) provides exceptional stability rarely seen in short peptides. Unlike many bioactive peptides that degrade rapidly, BPC-157 maintains structural integrity in various pH conditions and temperatures, facilitating diverse research protocols. RESEARCH FOCUS AREAS Published literature highlights BPC-157's investigation acro...

Form

Lyophilized Powder

Quantity

5mg

Storage

-20°C

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Customer Reviews (38)

Research brief

BPC-157 — Canada Research Brief

Origin and structure

BPC-157, short for Body Protection Compound-157, is a synthetic 15-amino-acid peptide derived from a fragment of a larger protein isolated from human gastric juice by Sikiric and colleagues at the University of Zagreb. Unlike most peptides of its size, BPC-157 is reported to be stable in human gastric fluid — a property that drove its initial interest as a potential oral research candidate.

Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. Molecular weight: 1,419.56 g/mol. CAS: 137525-51-0.

Preclinical mechanism

Preclinical rodent studies — the vast majority of BPC-157's literature — associate it with three pathways:

  1. VEGFR2 activation and angiogenesis. Several Sikiric-group papers link BPC-157 to upregulation of VEGFR2 expression and new blood-vessel formation in wound sites.
  2. Nitric oxide signalling. BPC-157 appears to interact with NO synthase pathways, which is the most-cited mechanism for its reported cytoprotective effects on the gastric mucosa.
  3. Dopaminergic and serotonergic modulation. A smaller body of work suggests effects on monoamine systems in rodent CNS models.

Human clinical evidence for BPC-157 is essentially absent. There are no completed phase-2 or phase-3 trials in humans registered with ClinicalTrials.gov for orthopaedic, neurological, or gastrointestinal endpoints as of publication.

Canadian research-use framing

BPC-157 is not a Health Canada approved drug, not a prescription item, and not a Natural Health Product. Any Canadian vendor selling BPC-157 as a treatment, therapy, or prescribable substance is operating outside the Food and Drugs Act. OVIOPEPTIDES sells BPC-157 strictly for non-clinical laboratory use. Read our peptides in Canada guide for the full regulatory framing.

Comparisons

Storage and reconstitution

BPC-157 ships as a lyophilised powder. Store the lyophilised vial at -20°C for long-term storage (24+ months) or 4°C for short-term (3-6 months). Reconstitute with bacteriostatic water following the steps in our reconstitution guide. Reconstituted material is stable refrigerated for approximately 2-4 weeks depending on concentration and handling.

Frequently asked questions

What is BPC-157?
BPC-157 (Body Protection Compound-157) is a 15-amino-acid synthetic pentadecapeptide derived from a protective protein isolated from human gastric juice. It has been studied in rodent preclinical models for roles in tissue repair, gut integrity, and angiogenesis. It is not approved for human use by any regulator.
Is BPC-157 approved in Canada?
No. BPC-157 is not approved by Health Canada for human or veterinary use, not a prescription drug, and not a Natural Health Product. It is sold in Canada strictly as a research chemical for non-clinical laboratory use only.
What is BPC-157's amino acid sequence?
The BPC-157 sequence is Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. It has a molecular weight of 1,419.56 g/mol, a molecular formula of C62H98N16O22, and CAS number 137525-51-0.
How does BPC-157 differ from TB-500?
BPC-157 is a 15-residue pentadecapeptide derived from gastric juice. TB-500 is a synthetic fragment related to Thymosin Beta-4. Both have been studied in preclinical models for tissue repair, but through different pathways — BPC-157 is associated with VEGFR2/angiogenesis, whereas TB-500 is associated with actin binding and cell migration. Neither is approved for human use.

References

  1. [1]Sikiric P, Seiwerth S, Rucman R, et al.. Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Current Pharmaceutical Design, 2011. PMID: 21548867
  2. [2]National Center for Biotechnology Information. PubChem CID 9941957 — BPC-157, 2024
  3. [3]Seiwerth S, Brcic L, Vuletic LB, et al.. BPC 157 and blood vessels. Current Pharmaceutical Design, 2014. PMID: 23782145

Related research

Frequently Asked Questions

What is BPC-157 used for in research?

BPC-157 is a body protection compound primarily used for tissue repair research. Promotes angiogenesis and tissue healing through growth factor modulation. Researchers study BPC-157 for its effects on wound healing, gut health, tendon repair.

Can I buy BPC-157 in Canada?

Yes, OVIOPEPTIDES ships BPC-157 across all Canadian provinces including Ontario, British Columbia, Alberta, Quebec, Manitoba, Saskatchewan, and all territories. Our BPC-157 is available for non-clinical laboratory research purposes only.

What purity is your BPC-157?

All BPC-157 from OVIOPEPTIDES is verified at 99%+ purity through independent third-party HPLC testing. Every order includes a Certificate of Analysis confirming purity, molecular weight, and identity verification.

How should I store BPC-157?

Store lyophilized BPC-157 powder at -20°C (freezer) in its original sealed vial. Once reconstituted with bacteriostatic water, refrigerate at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles.

How do I reconstitute BPC-157?

To reconstitute BPC-157, inject bacteriostatic water slowly against the vial wall. Swirl gently - never shake. Common reconstitution volumes are 1ml, 2ml, or 2.5ml depending on desired concentration. Allow the powder to dissolve completely before use.

Is BPC-157 legal in Canada?

BPC-157 is legal to purchase in Canada for non-clinical laboratory research purposes. It is not approved by Health Canada for therapeutic use and is not intended for human consumption. OVIOPEPTIDES sells BPC-157 strictly for research applications.

How does BPC-157 compare to tb-500?

BPC-157 and tb-500 are both used in tissue repair research but have different mechanisms. BPC-157 is a body protection compound, while tb-500 may work through different pathways. Researchers often study these peptides together for comparative analysis.

What documentation comes with BPC-157?

Every BPC-157 order from OVIOPEPTIDES includes a Certificate of Analysis (COA) documenting: HPLC purity results (99%+), mass spectrometry data, batch number, manufacturing date, and expiration date. This ensures full traceability for your research.