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CJC no DAC

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Research brief

CJC-1295 — Canada Research Brief

Last updated April 11, 2026

CJC-1295 is a synthetic long-acting GHRH analogue with an optional albumin-binding (DAC) moiety that extends its half-life to 6–8 days, studied preclinically for growth hormone release.

Key facts

Canonical nameCJC-1295
Alternate namesCJC-1295 DAC, DAC:GRF, Modified GRF 1-29 with DAC
Drug classGHRH (1-29) analogue with four substitutions and optional DAC linker
CAS number863288-34-0
Molecular formulaC152H252N44O42
Molecular weight3367.88 g/mol
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Reconstitution Guide

Add bacteriostatic water to achieve your desired concentration:

1ml BAC water5.0mg/ml
2ml BAC water2.5mg/ml
2.5ml BAC water2.0mg/ml

Inject water slowly against vial wall. Swirl gently, do not shake.

About This Product

CJC no DAC - Research Peptide for Research in Canada OVIOPEPTIDES offers premium CJC no DAC in Canada for scientific research. This research peptide is manufactured to the highest standards with 99%+ purity verification. PRODUCT OVERVIEW CJC no DAC is a research-grade peptide compound available as lyophilized powder in a sealed glass vial. Specialized peptide compound for laboratory research applications. RESEARCH APPLICATIONS Canadian researchers use CJC no DAC for studies in: • Laboratory research • In-vitro studies • Analytical testing QUALITY ASSURANCE Every batch of CJC no DAC from OVIOPEPTIDES undergoes rigorous third-party laboratory testing with HPLC purity analysis (99%+ verified), mass spectrometry confirmation, sterility testing, and Certificate of Analysis included. WHY CH...

Form

Lyophilized Powder

Quantity

5mg

Storage

-20°C

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Research brief

CJC-1295 — Canada Research Brief

Mechanism

CJC-1295 was developed by ConjuChem as a long-acting GHRH analogue. The backbone is the native GHRH (1-29) sequence with four substitutions (D-Ala²-Gln⁸-Ala¹⁵-Leu²⁷) that improve enzymatic stability. The DAC variant adds a maleimidopropionyl-lysine linker that forms a covalent bond with free cysteine residues on albumin shortly after injection — turning the peptide into an albumin-conjugated prodrug with a half-life of 6–8 days.

Mechanistically, CJC-1295 binds the GHRH receptor on pituitary somatotrophs and drives growth hormone secretion in pulses consistent with physiological GH rhythm. The DAC variant produces a sustained elevation in IGF-1 (the liver-derived output of the GH axis) while preserving physiological feedback via somatostatin — a distinction from exogenous recombinant GH.

Stacking with ipamorelin

The CJC-1295 + ipamorelin combination is the canonical GH-secretagogue research pair. GHRH analogues and ghrelin agonists act on different pituitary receptors, so their GH pulses add rather than compete. In rodent and early human studies the combination produced larger GH peaks than either compound alone at equivalent doses.

Storage

Store lyophilised CJC-1295 at −20°C protected from light. Reconstituted peptide is stable refrigerated at 2–8°C for 2–4 weeks. Avoid repeated freeze-thaw cycles.

Frequently asked questions

What is CJC-1295?
CJC-1295 is a synthetic 29-residue GHRH analogue built on the GRF(1-29) backbone with four substitutions plus a DAC linker. The standard "CJC-1295 with DAC" variant attaches a non-residue maleimidopropionyl lysine linker that binds covalently to plasma albumin via its free cysteine, extending the half-life to roughly 6–8 days. The "no-DAC" variant is equivalent to Modified GRF (1-29) and has a much shorter half-life.
What is the difference between CJC-1295 with DAC and without DAC?
CJC-1295 DAC carries an albumin-binding linker (Drug Affinity Complex) that extends its plasma half-life to 6–8 days and produces sustained growth hormone elevation. CJC-1295 no-DAC, functionally the same as Modified GRF (1-29), has a half-life of roughly 30 minutes and produces a pulsatile GH release pattern instead.
Why is CJC-1295 often stacked with ipamorelin?
GHRH analogues like CJC-1295 drive GH release from the pituitary via one receptor, while ghrelin receptor agonists like ipamorelin drive release via a different receptor. Used together, they produce a synergistic GH pulse larger than either alone. This is the scientific rationale behind the CJC-1295 + ipamorelin research combination. Neither compound is approved for human use.
What is CJC-1295's molecular weight?
CJC-1295 with DAC has a molecular weight of approximately 3,367.88 g/mol, a molecular formula of C152H252N44O42, and CAS number 863288-34-0.

References

  1. [1]Teichman SL, Neale A, Lawrence B, et al.. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. Journal of Clinical Endocrinology and Metabolism, 2006. PMID: 16352683
  2. [2]Wikipedia contributors. CJC-1295 — Wikipedia, 2024
  3. [3]National Center for Biotechnology Information. PubChem CID 16137828 — CJC-1295, 2024

Related research

Frequently Asked Questions

What is CJC no DAC used for in research?

CJC no DAC is a research peptide primarily used for scientific research. Specialized peptide compound for laboratory research applications. Researchers study CJC no DAC for its effects on laboratory research, in-vitro studies, analytical testing.

Can I buy CJC no DAC in Canada?

Yes, OVIOPEPTIDES ships CJC no DAC across all Canadian provinces including Ontario, British Columbia, Alberta, Quebec, Manitoba, Saskatchewan, and all territories. Our CJC no DAC is available for non-clinical laboratory research purposes only.

What purity is your CJC no DAC?

All CJC no DAC from OVIOPEPTIDES is verified at 99%+ purity through independent third-party HPLC testing. Every order includes a Certificate of Analysis confirming purity, molecular weight, and identity verification.

How should I store CJC no DAC?

Store lyophilized CJC no DAC powder at -20°C (freezer) in its original sealed vial. Once reconstituted with bacteriostatic water, refrigerate at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles.

How do I reconstitute CJC no DAC?

To reconstitute CJC no DAC, inject bacteriostatic water slowly against the vial wall. Swirl gently - never shake. Common reconstitution volumes are 1ml, 2ml, or 2.5ml depending on desired concentration. Allow the powder to dissolve completely before use.

Is CJC no DAC legal in Canada?

CJC no DAC is legal to purchase in Canada for non-clinical laboratory research purposes. It is not approved by Health Canada for therapeutic use and is not intended for human consumption. OVIOPEPTIDES sells CJC no DAC strictly for research applications.

What documentation comes with CJC no DAC?

Every CJC no DAC order from OVIOPEPTIDES includes a Certificate of Analysis (COA) documenting: HPLC purity results (99%+), mass spectrometry data, batch number, manufacturing date, and expiration date. This ensures full traceability for your research.