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IPAMORELIN
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OVIOPEPTIDES Price | $34.99 |
99%+ Purity
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Research brief
Ipamorelin — Canada Research Brief
Last updated April 11, 2026
Ipamorelin is a selective pentapeptide growth hormone secretagogue that stimulates GH release from the pituitary without significantly raising prolactin, ACTH, or cortisol.
Key facts
| Canonical name | Ipamorelin |
|---|---|
| Alternate names | NNC 26-0161 |
| Drug class | Selective growth hormone secretagogue (ghrelin receptor agonist) |
| CAS number | 170851-70-4 |
| Molecular formula | C38H49N9O5 |
| Molecular weight | 711.86 g/mol |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH₂ |
Reconstitution Guide
Add bacteriostatic water to achieve your desired concentration:
1ml BAC water5.0mg/ml
2ml BAC water2.5mg/ml
2.5ml BAC water2.0mg/ml
Inject water slowly against vial wall. Swirl gently, do not shake.
About This Product
IPAMORELIN Canada - Selective GH Secretagogue for Research Ipamorelin stands out among growth hormone secretagogues for its remarkable selectivity. This pentapeptide potently stimulates growth hormone release while producing minimal effects on cortisol, prolactin, or appetite - making it an ideal tool for studying isolated GH axis effects. SELECTIVITY PROFILE Unlike first-generation secretagogues such as GHRP-6, Ipamorelin activates growth hormone release without significant stimulation of other pituitary hormones. This selectivity allows researchers to study GH-specific effects without confounding variables from cortisol elevation or increased appetite. RESEARCH APPLICATIONS Scientists utilize Ipamorelin in investigations of: • Isolated GH release mechanisms • GHS-R1a receptor pharmaco...
Form
Lyophilized Powder
Quantity
5mg
Storage
-20°C
Share:
Customer Reviews (70)
IPAMORELIN
4.7 (70 reviews)
1
OVIOPEPTIDES Price | $34.99 |
Lab Results
Research brief
Ipamorelin — Canada Research Brief
Last updated April 11, 2026
Ipamorelin is a selective pentapeptide growth hormone secretagogue that stimulates GH release from the pituitary without significantly raising prolactin, ACTH, or cortisol.
Key facts
| Canonical name | Ipamorelin |
|---|---|
| Alternate names | NNC 26-0161 |
| Drug class | Selective growth hormone secretagogue (ghrelin receptor agonist) |
| CAS number | 170851-70-4 |
| Molecular formula | C38H49N9O5 |
| Molecular weight | 711.86 g/mol |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH₂ |
Reconstitution Guide
Add bacteriostatic water to achieve your desired concentration:
1ml BAC water5.0mg/ml
2ml BAC water2.5mg/ml
2.5ml BAC water2.0mg/ml
Inject water slowly against vial wall. Swirl gently, do not shake.
About This Product
IPAMORELIN Canada - Selective GH Secretagogue for Research Ipamorelin stands out among growth hormone secretagogues for its remarkable selectivity. This pentapeptide potently stimulates growth hormone release while producing minimal effects on cortisol, prolactin, or appetite - making it an ideal tool for studying isolated GH axis effects. SELECTIVITY PROFILE Unlike first-generation secretagogues such as GHRP-6, Ipamorelin activates growth hormone release without significant stimulation of other pituitary hormones. This selectivity allows researchers to study GH-specific effects without confounding variables from cortisol elevation or increased appetite. RESEARCH APPLICATIONS Scientists utilize Ipamorelin in investigations of: • Isolated GH release mechanisms • GHS-R1a receptor pharmaco...
Form
Lyophilized Powder
Quantity
5mg
Storage
-20°C
99%+ Purity
3rd Party Tested
Fast Shipping
Discreet Package
Share:
Customer Reviews (70)
Research brief
Ipamorelin — Canada Research Brief
Mechanism and selectivity
Ipamorelin is a pentapeptide designed at Novo Nordisk by screening derivatives of GHRP-1 for selective GH release. The key finding — reported by Raun et al. (European Journal of Endocrinology 1998) — was that ipamorelin stimulated GH release in rats and pigs at potencies equivalent to GHRP-2 and GHRP-6 but, uniquely, did not produce significant elevations in ACTH, cortisol, or prolactin.
That selectivity is the defining feature of ipamorelin in the literature. The structural reason is that its D-2-Nal and D-Phe substitutions favour binding to the ghrelin/GHS-R1a receptor without activating the secondary receptors responsible for the ACTH/cortisol arm of earlier GHRPs.
Research pairing with CJC-1295
Ipamorelin is most commonly studied in combination with a GHRH analogue (sermorelin, modified GRF 1-29, or CJC-1295) because the two receptors converge on the same somatotroph. The combined GH pulse is larger than either alone — see our CJC-1295 vs ipamorelin comparison for the mechanistic breakdown.
Storage
Store lyophilised ipamorelin at −20°C protected from light. Reconstituted peptide is stable refrigerated at 2–8°C for 2–4 weeks. Avoid repeated freeze-thaw cycles.
Frequently asked questions
What is ipamorelin?
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) developed by Novo Nordisk. It acts as an agonist at the ghrelin receptor (GHS-R1a) on pituitary somatotrophs and stimulates pulsatile release of endogenous growth hormone. It was selected for development precisely because it avoids the off-target hormonal releases seen with earlier GHRPs.
How is ipamorelin different from GHRP-2 and GHRP-6?
All three are ghrelin receptor agonists that release endogenous GH. Ipamorelin is the most selective — it does not significantly raise prolactin, ACTH, or cortisol at research doses. GHRP-2 causes modest rises in cortisol and prolactin. GHRP-6 is known for a strong appetite-stimulating effect via hypothalamic ghrelin circuits, which the other two lack.
Why is ipamorelin often paired with CJC-1295?
GHRH analogues like CJC-1295 stimulate growth hormone release via the GHRH receptor. Ghrelin agonists like ipamorelin stimulate release via the ghrelin/GHS-R1a receptor. The two pathways converge on the same cell type, so combining them produces larger GH pulses than either alone — the rationale for the CJC-1295 + ipamorelin research stack.
What is ipamorelin's molecular weight?
Ipamorelin has a molecular weight of 711.86 g/mol, a molecular formula of C38H49N9O5, and CAS number 170851-70-4. Its sequence is Aib-His-D-2-Nal-D-Phe-Lys-NH₂.
References
- [1]Raun K, Hansen BS, Johansen NL, et al.. Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 1998. PMID: 9849822
- [2]National Center for Biotechnology Information. PubChem CID 9831659 — Ipamorelin, 2024
- [3]Wikipedia contributors. Ipamorelin — Wikipedia, 2024
Related research
Frequently Asked Questions
What is IPAMORELIN used for in research?
IPAMORELIN is a growth hormone secretagogue primarily used for growth hormone research. Selective GHSR agonist that stimulates GH release without affecting cortisol. Researchers study IPAMORELIN for its effects on muscle growth, fat loss, bone density.
Can I buy IPAMORELIN in Canada?
Yes, OVIOPEPTIDES ships IPAMORELIN across all Canadian provinces including Ontario, British Columbia, Alberta, Quebec, Manitoba, Saskatchewan, and all territories. Our IPAMORELIN is available for non-clinical laboratory research purposes only.
What purity is your IPAMORELIN?
All IPAMORELIN from OVIOPEPTIDES is verified at 99%+ purity through independent third-party HPLC testing. Every order includes a Certificate of Analysis confirming purity, molecular weight, and identity verification.
How should I store IPAMORELIN?
Store lyophilized IPAMORELIN powder at -20°C (freezer) in its original sealed vial. Once reconstituted with bacteriostatic water, refrigerate at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles.
How do I reconstitute IPAMORELIN?
To reconstitute IPAMORELIN, inject bacteriostatic water slowly against the vial wall. Swirl gently - never shake. Common reconstitution volumes are 1ml, 2ml, or 2.5ml depending on desired concentration. Allow the powder to dissolve completely before use.
Is IPAMORELIN legal in Canada?
IPAMORELIN is legal to purchase in Canada for non-clinical laboratory research purposes. It is not approved by Health Canada for therapeutic use and is not intended for human consumption. OVIOPEPTIDES sells IPAMORELIN strictly for research applications.
How does IPAMORELIN compare to cjc-1295?
IPAMORELIN and cjc-1295 are both used in growth hormone research but have different mechanisms. IPAMORELIN is a growth hormone secretagogue, while cjc-1295 may work through different pathways. Researchers often study these peptides together for comparative analysis.
What documentation comes with IPAMORELIN?
Every IPAMORELIN order from OVIOPEPTIDES includes a Certificate of Analysis (COA) documenting: HPLC purity results (99%+), mass spectrometry data, batch number, manufacturing date, and expiration date. This ensures full traceability for your research.
