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TB-500
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OVIOPEPTIDES Price | $70.00 |
99%+ Purity
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Lab Results
Research brief
TB-500 — Canada Research Brief
Last updated April 11, 2026
TB-500 is a synthetic acetylated heptapeptide corresponding to the active fragment (residues 17–23) of thymosin β4, studied preclinically for actin binding, angiogenesis, and wound repair.
Key facts
| Canonical name | TB-500 |
|---|---|
| Alternate names | Thymosin beta-4 fragment 17-23, Ac-LKKTETQ, Tβ4 active fragment |
| Drug class | Synthetic thymosin β4 fragment (actin-binding research peptide) |
| CAS number | 77591-33-4 |
| Molecular formula | C39H67N11O14 |
| Molecular weight | 889.98 g/mol |
| Sequence | Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln |
Reconstitution Guide
Add bacteriostatic water to achieve your desired concentration:
1ml BAC water5.0mg/ml
2ml BAC water2.5mg/ml
2.5ml BAC water2.0mg/ml
Inject water slowly against vial wall. Swirl gently, do not shake.
About This Product
TB-500 Canada - Thymosin Beta-4 Fragment for Research TB-500, a synthetic version of the naturally occurring 43-amino acid peptide Thymosin Beta-4, plays a central role in cell migration and tissue repair research. As a key actin-sequestering protein, TB-500 helps researchers understand fundamental mechanisms of wound healing and inflammation modulation. UNDERSTANDING TB-500'S ROLE Thymosin Beta-4 is one of the most abundant small proteins in mammalian cells. TB-500 contains the active region responsible for promoting cell migration, blood vessel formation, and tissue remodeling. The peptide interacts with actin, a critical cytoskeletal protein, to facilitate cellular movement and repair processes. SCIENTIFIC INVESTIGATION AREAS TB-500 appears extensively in published research examining...
Form
Lyophilized Powder
Quantity
5mg
Storage
-20°C
Share:
Customer Reviews (67)
TB-500
4.7 (67 reviews)
1
OVIOPEPTIDES Price | $70.00 |
Lab Results
Research brief
TB-500 — Canada Research Brief
Last updated April 11, 2026
TB-500 is a synthetic acetylated heptapeptide corresponding to the active fragment (residues 17–23) of thymosin β4, studied preclinically for actin binding, angiogenesis, and wound repair.
Key facts
| Canonical name | TB-500 |
|---|---|
| Alternate names | Thymosin beta-4 fragment 17-23, Ac-LKKTETQ, Tβ4 active fragment |
| Drug class | Synthetic thymosin β4 fragment (actin-binding research peptide) |
| CAS number | 77591-33-4 |
| Molecular formula | C39H67N11O14 |
| Molecular weight | 889.98 g/mol |
| Sequence | Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln |
Reconstitution Guide
Add bacteriostatic water to achieve your desired concentration:
1ml BAC water5.0mg/ml
2ml BAC water2.5mg/ml
2.5ml BAC water2.0mg/ml
Inject water slowly against vial wall. Swirl gently, do not shake.
About This Product
TB-500 Canada - Thymosin Beta-4 Fragment for Research TB-500, a synthetic version of the naturally occurring 43-amino acid peptide Thymosin Beta-4, plays a central role in cell migration and tissue repair research. As a key actin-sequestering protein, TB-500 helps researchers understand fundamental mechanisms of wound healing and inflammation modulation. UNDERSTANDING TB-500'S ROLE Thymosin Beta-4 is one of the most abundant small proteins in mammalian cells. TB-500 contains the active region responsible for promoting cell migration, blood vessel formation, and tissue remodeling. The peptide interacts with actin, a critical cytoskeletal protein, to facilitate cellular movement and repair processes. SCIENTIFIC INVESTIGATION AREAS TB-500 appears extensively in published research examining...
Form
Lyophilized Powder
Quantity
5mg
Storage
-20°C
99%+ Purity
3rd Party Tested
Fast Shipping
Discreet Package
Share:
Customer Reviews (67)
Research brief
TB-500 — Canada Research Brief
Structure and origin
TB-500 is the seven-residue actin-binding motif of thymosin β4, identified by Van Troys et al. (EMBO J 1996) through peptide mapping of the full-length Tβ4 molecule. The fragment retains much of Tβ4's cellular activity in in-vitro assays while being far easier to synthesise and dissolve — which is why commercial research-peptide inventories usually sell "TB-500" rather than full-length thymosin β4.
Preclinical pathways
Preclinical research on TB-500 and its parent Tβ4 converges on three pathways:
- Actin sequestering and cell migration. Both molecules bind G-actin monomers and modulate the pool available for filament assembly — the mechanism for their reported effects on cell motility and tissue remodelling.
- Angiogenesis. In rodent wound and cardiac injury models (Bock- Marquette et al., Nature 2004), Tβ4 treatment promoted new blood-vessel formation.
- Anti-inflammatory signalling. Tβ4 has been linked to modulation of NF-κB in multiple in-vitro systems, with effects on cytokine profiles downstream.
Note that most published evidence for these pathways uses full-length Tβ4. TB-500 is assumed to retain the actin-binding activity but not necessarily all of the non-actin-related effects.
Comparisons
- BPC-157 vs TB-500 — pathway and evidence quality differences.
Storage
Store lyophilised TB-500 at −20°C. Reconstituted peptide is stable refrigerated at 2–8°C for approximately 2–4 weeks.
Frequently asked questions
What is TB-500?
TB-500 is a synthetic acetylated heptapeptide (Ac-LKKTETQ-NH₂) that corresponds to residues 17–23 of thymosin β4, the actin-binding region of the full-length Tβ4 peptide. It is used in preclinical research on cell migration, angiogenesis, and wound repair as a short, soluble proxy for full-length thymosin β4 activity.
Is TB-500 the same as thymosin β4?
No. Thymosin β4 is a naturally occurring 43-amino-acid peptide and the principal actin-sequestering molecule in mammalian cells. TB-500 is a much shorter synthetic fragment containing only the actin-binding motif. They share biological activity in some assays but have different pharmacokinetics, stability, and manufacturing complexity.
How does TB-500 differ from BPC-157?
TB-500 and BPC-157 are both studied for tissue repair in rodent models, but through different mechanisms. TB-500 acts via actin binding and effects on cell migration and angiogenesis. BPC-157 is associated with VEGFR2 signalling and nitric-oxide pathways. Neither is approved for human use in Canada. See our [BPC-157 vs TB-500 comparison](/compare/bpc-157-vs-tb-500) for details.
What is TB-500's molecular weight?
TB-500 has a molecular weight of 889.98 g/mol, a molecular formula of C39H67N11O14, and is commonly registered under CAS 77591-33-4 (shared with thymosin β4). Its sequence is Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln.
References
- [1]Bock-Marquette I, Saxena A, White MD, et al.. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature, 2004. PMID: 15565145
- [2]Wikipedia contributors. Thymosin beta-4 — Wikipedia, 2024
- [3]National Center for Biotechnology Information. PubChem CID 16132341 — TB-500 fragment, 2024
Related research
Frequently Asked Questions
What is TB-500 used for in research?
TB-500 is a thymosin beta-4 fragment primarily used for tissue regeneration research. Regulates actin for cell migration and wound healing. Researchers study TB-500 for its effects on injury recovery, inflammation, tissue repair.
Can I buy TB-500 in Canada?
Yes, OVIOPEPTIDES ships TB-500 across all Canadian provinces including Ontario, British Columbia, Alberta, Quebec, Manitoba, Saskatchewan, and all territories. Our TB-500 is available for non-clinical laboratory research purposes only.
What purity is your TB-500?
All TB-500 from OVIOPEPTIDES is verified at 99%+ purity through independent third-party HPLC testing. Every order includes a Certificate of Analysis confirming purity, molecular weight, and identity verification.
How should I store TB-500?
Store lyophilized TB-500 powder at -20°C (freezer) in its original sealed vial. Once reconstituted with bacteriostatic water, refrigerate at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles.
How do I reconstitute TB-500?
To reconstitute TB-500, inject bacteriostatic water slowly against the vial wall. Swirl gently - never shake. Common reconstitution volumes are 1ml, 2ml, or 2.5ml depending on desired concentration. Allow the powder to dissolve completely before use.
Is TB-500 legal in Canada?
TB-500 is legal to purchase in Canada for non-clinical laboratory research purposes. It is not approved by Health Canada for therapeutic use and is not intended for human consumption. OVIOPEPTIDES sells TB-500 strictly for research applications.
How does TB-500 compare to bpc-157?
TB-500 and bpc-157 are both used in tissue regeneration research but have different mechanisms. TB-500 is a thymosin beta-4 fragment, while bpc-157 may work through different pathways. Researchers often study these peptides together for comparative analysis.
What documentation comes with TB-500?
Every TB-500 order from OVIOPEPTIDES includes a Certificate of Analysis (COA) documenting: HPLC purity results (99%+), mass spectrometry data, batch number, manufacturing date, and expiration date. This ensures full traceability for your research.
