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EPITHALON
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99%+ Purity
3rd Party Tested
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Lab Results
Lab results available upon request
Research brief
Epithalon — Canada Research Brief
Last updated April 11, 2026
Epithalon is a synthetic tetrapeptide developed in Russia as a short analogue of the pineal peptide epithalamin, studied preclinically for telomerase activity, circadian rhythm, and age-related endpoints.
Key facts
| Canonical name | Epithalon |
|---|---|
| Alternate names | Epitalon, Epithalamin tetrapeptide |
| Drug class | Synthetic tetrapeptide (longevity research) |
| CAS number | 307297-39-8 |
| Molecular formula | C14H22N4O9 |
| Molecular weight | 390.35 g/mol |
| Sequence | Ala-Glu-Asp-Gly |
Reconstitution Guide
Add bacteriostatic water to achieve your desired concentration:
1ml BAC water5.0mg/ml
2ml BAC water2.5mg/ml
2.5ml BAC water2.0mg/ml
Inject water slowly against vial wall. Swirl gently, do not shake.
About This Product
EPITHALON Canada - Telomerase Activation Research Peptide Epithalon, a synthetic tetrapeptide (Ala-Glu-Asp-Gly), emerged from decades of Russian longevity research. This small peptide serves as a key research tool for scientists investigating telomerase activation, pineal gland function, and cellular aging mechanisms. MECHANISM OF INTEREST Epithalon research centers on its potential to activate telomerase, the enzyme responsible for maintaining telomere length. Telomeres protect chromosome ends during cell division, and their progressive shortening correlates with cellular aging. Researchers study Epithalon's effects on telomerase expression in various cell types. AREAS OF SCIENTIFIC INQUIRY Published studies examine Epithalon's role in: • Telomerase enzyme activation • Melatonin regula...
Form
Lyophilized Powder
Quantity
5mg
Storage
-20°C
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Customer Reviews (26)
EPITHALON
4.8 (26 reviews)
1
Lab Results
Lab results available upon request
Research brief
Epithalon — Canada Research Brief
Last updated April 11, 2026
Epithalon is a synthetic tetrapeptide developed in Russia as a short analogue of the pineal peptide epithalamin, studied preclinically for telomerase activity, circadian rhythm, and age-related endpoints.
Key facts
| Canonical name | Epithalon |
|---|---|
| Alternate names | Epitalon, Epithalamin tetrapeptide |
| Drug class | Synthetic tetrapeptide (longevity research) |
| CAS number | 307297-39-8 |
| Molecular formula | C14H22N4O9 |
| Molecular weight | 390.35 g/mol |
| Sequence | Ala-Glu-Asp-Gly |
Reconstitution Guide
Add bacteriostatic water to achieve your desired concentration:
1ml BAC water5.0mg/ml
2ml BAC water2.5mg/ml
2.5ml BAC water2.0mg/ml
Inject water slowly against vial wall. Swirl gently, do not shake.
About This Product
EPITHALON Canada - Telomerase Activation Research Peptide Epithalon, a synthetic tetrapeptide (Ala-Glu-Asp-Gly), emerged from decades of Russian longevity research. This small peptide serves as a key research tool for scientists investigating telomerase activation, pineal gland function, and cellular aging mechanisms. MECHANISM OF INTEREST Epithalon research centers on its potential to activate telomerase, the enzyme responsible for maintaining telomere length. Telomeres protect chromosome ends during cell division, and their progressive shortening correlates with cellular aging. Researchers study Epithalon's effects on telomerase expression in various cell types. AREAS OF SCIENTIFIC INQUIRY Published studies examine Epithalon's role in: • Telomerase enzyme activation • Melatonin regula...
Form
Lyophilized Powder
Quantity
5mg
Storage
-20°C
99%+ Purity
3rd Party Tested
Fast Shipping
Discreet Package
Share:
Customer Reviews (26)
Research brief
Epithalon — Canada Research Brief
Origin and rationale
Epithalon was developed in the 1990s by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology. It is the short synthetic analogue of epithalamin, a peptide preparation originally isolated from bovine pineal gland extract and used in Soviet/ Russian clinical practice as a putative anti-ageing agent. Khavinson selected the minimal active sequence (Ala-Glu-Asp-Gly) from proteomic analyses of the pineal extract.
Preclinical profile
The Khavinson group has published extensively on epithalon over four decades. Key reported findings include:
- Effects on telomerase activity and telomere length in human somatic cell cultures (fibroblasts, lymphocytes).
- Lifespan extension in rodent models when dosed over long courses.
- Circadian/melatonin effects consistent with a pineal-axis-modulating mechanism — plausible given the peptide's epithalamin ancestry.
- Immunomodulation and hormonal normalisation in ageing animals.
The important methodological caveat is that the bulk of the literature comes from a single research group. Independent replication at scale is limited, which is a standard concern for interpreting claimed mechanisms.
Storage
Store lyophilised epithalon at −20°C. Reconstituted peptide is stable refrigerated at 2–8°C for 2–4 weeks.
Frequently asked questions
What is epithalon?
Epithalon (also spelled epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. It was developed by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology as a short synthetic analogue of epithalamin, a peptide preparation originally isolated from bovine pineal gland extract.
Is epithalon approved as a longevity drug?
No. Epithalon has no clinical approval in Canada, the U.S., the EU, or any other major jurisdiction. Published work is almost entirely from the Khavinson group in St. Petersburg and has not been independently replicated at scale. It is sold in Canada strictly as a research chemical for non-clinical laboratory research.
Does epithalon affect telomerase?
Preclinical papers from the Khavinson group report effects on telomerase activity and telomere length in cell culture and in rodent models. These findings are the basis for epithalon's reputation as a "longevity peptide". Independent replication outside the St. Petersburg lab is limited, which is an important caveat when interpreting the claimed mechanism.
What is epithalon's molecular weight?
Epithalon has a molecular weight of 390.35 g/mol, a molecular formula of C14H22N4O9, and CAS number 307297-39-8. Its four-residue sequence is Ala-Glu-Asp-Gly.
References
- [1]Khavinson VKh. Peptides and Ageing. Neuroendocrinology Letters, 2002. PMID: 12374906
- [2]Wikipedia contributors. Epitalon — Wikipedia, 2024
- [3]National Center for Biotechnology Information. PubChem CID 219042 — Epithalon, 2024
Related research
Frequently Asked Questions
What is EPITHALON used for in research?
EPITHALON is a telomerase activator primarily used for longevity and anti-aging research. Stimulates telomerase production to protect telomere length. Researchers study EPITHALON for its effects on anti-aging, cellular longevity, immune function.
Can I buy EPITHALON in Canada?
Yes, OVIOPEPTIDES ships EPITHALON across all Canadian provinces including Ontario, British Columbia, Alberta, Quebec, Manitoba, Saskatchewan, and all territories. Our EPITHALON is available for non-clinical laboratory research purposes only.
What purity is your EPITHALON?
All EPITHALON from OVIOPEPTIDES is verified at 99%+ purity through independent third-party HPLC testing. Every order includes a Certificate of Analysis confirming purity, molecular weight, and identity verification.
How should I store EPITHALON?
Store lyophilized EPITHALON powder at -20°C (freezer) in its original sealed vial. Once reconstituted with bacteriostatic water, refrigerate at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles.
How do I reconstitute EPITHALON?
To reconstitute EPITHALON, inject bacteriostatic water slowly against the vial wall. Swirl gently - never shake. Common reconstitution volumes are 1ml, 2ml, or 2.5ml depending on desired concentration. Allow the powder to dissolve completely before use.
Is EPITHALON legal in Canada?
EPITHALON is legal to purchase in Canada for non-clinical laboratory research purposes. It is not approved by Health Canada for therapeutic use and is not intended for human consumption. OVIOPEPTIDES sells EPITHALON strictly for research applications.
How does EPITHALON compare to ghk-cu?
EPITHALON and ghk-cu are both used in longevity and anti-aging research but have different mechanisms. EPITHALON is a telomerase activator, while ghk-cu may work through different pathways. Researchers often study these peptides together for comparative analysis.
What documentation comes with EPITHALON?
Every EPITHALON order from OVIOPEPTIDES includes a Certificate of Analysis (COA) documenting: HPLC purity results (99%+), mass spectrometry data, batch number, manufacturing date, and expiration date. This ensures full traceability for your research.
